Good fences make good neighbors
Our genome is a patchwork of neighborhoods that couldn't be more different: Some areas are hustling and bustling with gene activity, while others are sparsely populated and in perpetual lock-down....
View ArticlePancreatic cancer: Researchers find drug that reverses resistance to...
For the first time researchers have shown that by inhibiting the action of an enzyme called TAK-1, it is possible to make pancreatic cancer cells sensitive to chemotherapy, opening the way for the...
View ArticleNewly discovered mechanism allows cells to change state
Cells are not static. They can transform themselves over time — but change can have dangerous implications. Benign cells, for example, can suddenly change into cancerous ones.
View ArticleReaching the summit of protein dynamics
Understanding the incredibly speedy atomic mechanisms at work when a protein transitions from one shape to another has been an elusive scientific goal for years, but an essential one for elucidating...
View ArticleStem-cell activators switch function, repress mature cells
In a developing animal, stem cells proliferate and differentiate to form the organs needed for life. A new study shows how a crucial step in this process happens and how a reversal of that step...
View ArticleParadigm changing mechanism is revealed for the control of gene expression in...
A new study led by researchers at NYU Langone Medical Center is shedding new light on the action of Rho, a key regulatory protein in E. coli and many other bacteria. The study published in the January...
View ArticleNew approach to treating breast and prostate cancers
In a new approach to developing treatments for breast cancer, prostate cancer and enlarged hearts, Loyola University Chicago Stritch School of Medicine researchers are zeroing in on a workhorse protein...
View ArticleDiscovery of key regulatory factor may offer new treatment target for...
(PhysOrg.com) -- Researchers at Indiana University School of Medicine have identified a mechanism that causes inflammation in asthma and other allergic diseases, a discovery that could lead to new...
View ArticleMicroRNA can move between cells
(PhysOrg.com) -- MicroRNAs can move between cells and play a role in their communication. This discovery was made by plant researchers at Uppsala University together with colleagues from Finland and...
View ArticleNew role for master regulator in cell metabolism, response to stress
AMP-activated protein kinase, or AMPK, is a master regulator protein of metabolism that is conserved from yeast to humans. When a cell is low on fuel, AMPK shuts down processes that use energy and...
View ArticleResearchers find way to make cancer cells more mortal
Washington State University researchers have discovered a way to help cancer cells age and die, creating a promising avenue for slowing and even stopping the growth of tumors.
View ArticleScientists find unsuspected molecular link between obesity and insulin...
A new understanding of insulin resistance and the action of diabetes drugs such as Avandia and Actos could pave the way for improved medications that are more selective and safer, say scientists from...
View ArticleStudy finds protein that sets the stage for exchanges of DNA code in eggs and...
A team led by a scientist at the University of Pittsburgh School of Medicine has discovered a regulatory protein that influences where genetic material gets swapped between maternal and paternal...
View ArticleNew finding in ribosome signaling may lead to improved antibiotics
(PhysOrg.com) -- Researchers at the University of Illinois at Chicago have discovered a signaling mechanism in the bacterial ribosome that detects proteins that activate genes for antibiotic resistance.
View ArticlePredicting the fate of personalized cells next step toward new therapies
Discovering the step-by-step details of the path embryonic cells take to develop into their final tissue type is the clinical goal of many stem cell biologists. To that end, Kenneth S. Zaret, PhD,...
View ArticleConnecting the dots: Nanoscale approach to biomaterials
Researchers at the University of Pittsburgh School of Dental Medicine are piecing together the process of tooth enamel biomineralization, which could lead to novel nanoscale approaches to developing...
View ArticleKnocking out key protein in mice boosts insulin sensitivity
By knocking out a key regulatory protein, scientists at the University of California, San Diego School of Medicine and the Ecole Polytechnique Federale de Lausanne (EPFL) in Switzerland dramatically...
View ArticleImproving crops from the roots up
Research involving scientists at The University of Nottingham has taken us a step closer to breeding hardier crops that can better adapt to different environmental conditions and fight off attack from...
View ArticleReversible oxygen-sensing 'switching' mechanism discovered
Bacteria that cause disease in humans have a 'reversible switching mechanism' that allows them to adapt to environments lacking oxygen, scientists at the University of East Anglia (UEA) have found.
View ArticleCell biologists identify new protein key to asymmetric cell division
Recently biologists at the University of Massachusetts Amherst led by Wei-lih Lee have identified a new molecular player in asymmetric cell division, a regulatory protein named She1 whose role in...
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